Evaluation of MK-870: a new potassium-sparing diuretic.
نویسندگان
چکیده
Acute Myocardial Infarction-Bay et al. MEDImAL JOURNAL 143 sweating, and congestion of the neck veins. In two patients retrosternal pains were intensified.
منابع مشابه
Amiloride hydrochloride in hypertensive patients.
In man amiloride hydrochloride (MK-870) has been shown to be an orally effective diuretic which causes a positive potassium balance. It also enhances the saluretic effects of hydrochlorothiazide and ethacrynic acid and in addition prevents the negative potassium balance caused by these diuretics (Wilson et al., 1966; Gombos et al., 1966). Gombos et al. also studied its effects in 10 hypertensiv...
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The active potassium influx in the human red blood cell is inhibited by strophanthidin, ethacrynic acid, and MK-870 (a new diuretic), and the degree of inhibition is greater at low concentrations of extracellular potassium than at high. In the case of ethacrynic acid, potassium appears to diminish the rate of combination of the drug with the transport system. The kinetic behavior of the active ...
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The objective of this teaching session with Professor McCance is to develop an approach to the management of patients with a very low plasma potassium (K(+)) concentration (P(K)). The session begins with a quiz based on six recent medical consultations for a P(K) < 2 mmol/l. Professor McCance outlined how he would proceed with his diagnosis and therapy, using the synopsis that described each pa...
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In view of evidence suggesting an association of mild hypokalaemia with cardiac arrhythmia, the arrhythmogenic potentials of potassium losing and potassium sparing diuretic treatments were compared in a controlled prospective crossover study of 10 patients with mild hypertension and ischaemic heart disease. Mean (SEM) plasma potassium was 4.3(0.06) mmol/l and 3.3(0.07) mmol/l after potassium sp...
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عنوان ژورنال:
- British medical journal
دوره 1 5533 شماره
صفحات -
تاریخ انتشار 1967